Thoughts

Angiogenesis Demystified

Angiogenesis.

At first glance, it can seem like an intimidating word. A lot of people may inadvertently find their eyes glazing over whenever they encounter medical terminology with more than a few syllables.

Angiogenesis forms blood vessels from existing blood vessels

But it’s well worth learning what this particular process is for anyone considering bone or tissue grafts, because the effectiveness of the entire procedure depends on angiogenesis.

In fact, as part of our efforts to create better cellular allografts, Burst Biologics has had to find ways to encourage angiogenesis. Read on to understand how the process works and why it matters.

What Exactly is Angiogenesis?

At a basic level, angiogenesis is simply the formation and development of new blood vessels. More precisely, it forms new capillary blood vessels from preexisting blood vessels.

If you’re a word nerd, you may find it helpful to consider the term based on its two roots:

  • Angio – blood vessel
  • Genesis – creation

In addition to angiogenesis, there’s vasculogenesis. This is a different but related process in which brand new blood vessels are formed from angioblasts (aka endothelial precursor cells). You’ll generally only see vasculogenesis in an embryo – by the time an individual reaches adulthood, the formation of new blood vessels occurs primarily through angiogenesis.

Why is Angiogenesis Important?

The reason you should care about angiogenesis is for its essential role in wound healing and bone formation. Yes, it’s actually needed in order for bone to form!

For example, in the case of a spinal fusion, there’s typically some kind of a gap between two vertebrae that needs to be filled in with natural bone. How does a physician make that happen?

Well, a bone graft like our BioBurst strip can help. When it’s placed in the cavity, the strip creates an osteoconductive matrix as a scaffold for new bone formation. However, just as important is the inclusion of powerful natural growth factors and cytokines. One of these is the VEGF, or vascular endothelial growth factor, a signal that tells the body to grow blood vessels in the area.

Angiogenesis matters because bone is a highly vascularized tissue that relies on the connection between bone cells and blood vessels in order to maintain skeletal integrity. If you have the ingredients in place for bone growth, but not for blood vessel formation, the procedure isn’t going to have the greatest impact.

Angiogenesis encourages blood vessel growth

And why are blood vessels so important? Ultimately, bone and tissue regeneration require angiogenesis – the formation of a functional microvascular network – because new blood vessels promote much-needed blood circulation to areas in the body that need nutrients. In our spinal fusion case, the affected area needs a lot of raw material to rebuild bone, and blood vessels make that possible.

Angiogenesis in Allografts

So, what does all this mean in plain English? It means that if you want an effective allograft, you need to consider whether the products you rely on induce the creation of new blood vessels.

When you consider effectiveness in biologic applications, speed is a big motivator. Fortunately, a process like angiogenesis can directly boost the speed of healing, because it creates more capillaries that allow more nutrients to be delivered within the same timeframe.

But that’s not all. As important as this specific process is, there’s another key point here, which is that bodily processes are interconnected. Like with digestion or respiration, the formation of bone (ie osteogenesis) doesn’t occur in a vacuum.

That’s why regenerative medicine products need angiogenesis as part of the bone consolidation process, and why it’s so important to continue researching ways of inducing it for healing.

Interested in learning more? We’ve recently released a new BioBurst Fluid research brochure that delves into BioBurst Fluid and its unique angiogenic properties, as well as the science behind angiogenesis.

Head on over to My BioPortal to grab a copy or ask your rep about it today!


Regenerative Medicine Solutions for the US Military

We’ve seen huge strides in regenerative medicine solutions over the past few decades. Thanks to the field’s groundbreaking gene, cell, and tissue-based therapies, countless people can now enjoy pain relief and restored functionality after injury or deterioration.

The pace of new discoveries in regenerative medicine is only accelerating, and Burst Biologics is proud to be a part of this progress, creating innovative new products that help consolidate bone, regenerate soft tissue, and more.

Of course, our work to date has focused on patients and physicians in the civilian world, but we’re excited to announce that we’ll also be conducting research on behalf of the military! Soon, our newest staff Ph.D. will begin applying for U.S. Department of Defense (DoD) grants related to gene and cellular therapy on behalf of Burst Biologics.

US soldiers benefit from regenerative medicine solutions

As a company, we have staff with close associations to the military, including our CEO Christopher Jones, a veteran who’s designated Burst Biologics as a veteran-owned business. That’s why this next step is meaningful for the company, both personally and professionally.

It’s inspiring to us that the research we do will end up saving lives and dramatically improving the quality of life of wounded soldiers.

Regeneration From the Wounds of War

It may have gone under your radar, but the US military has already taken note of the power of regenerative medicine.

In fact, the US Army has employed regenerative medicine solutions to help wounded service members over the last decade. This is partly thanks to an organization called AFIRM – the Armed Forces Institute of Regenerative Medicine – which helps develop advanced treatment options for injured servicemen and women.

Armed Forces Institute of Regenerative Medicine

It’s important to note the difference between treating civilian patients and active soldiers wounded in the line of duty. Many service members sustain unique tissue injuries and complications in combat due to bullets, shrapnel, and high-energy explosives. As a result, the damage that must be healed is far more extensive than in most civilian injuries.

War trauma often requires restoration of complex tissues involving a number of integrated cell types – in civilian patients, on the other hand, physicians can use regenerative medicine solutions for a targeted, localized function, such as mesenchymal stem cells in the spinal cord for bone growth.

The Emergence of New Regenerative Medicine Solutions

Obviously, there are serious challenges associated with treating wartime wounds, which is why organizations like AFIRM are so important. In conjunction with the research undertaken at a number of medical technology companies, AFIRM has already been able to successfully treat severely burned skin with some novel solutions:

  • Embrace. A stress-shielding surgical bandage that reduces scarring after surgical intervention.
  • ReCell. A “spray-on” skin designed for first or second degree burns.
  • StrataGraft. A durable skin substitute that will heal normally after application.

These particular skin healing innovations dramatically improve treatment effectiveness and make it possible for soldiers to recover without the need for donor sites. There have also been major advancements in other areas, such as hand and face transplantations, with further progress underway on vascular composite tissue allotransplantation, craniomaxillofacial reconstruction, and extremity injury treatment.  

Honoring US military servicemen and women

Ultimately, the goal is to fully heal anyone who’s been injured in battle, which includes both civilians and wounded soldiers. Regenerative medicine solutions come into play when conventional treatment options aren’t effective enough to restore lost functionality, form, and comfort.

Applying for DoD Grants

AFIRM is playing a key role in the revolution of regenerative medicine solutions for the military, because the Army doesn’t have the expertise or the budget to develop novel medical solutions on its own. Instead, the DoD defines projects that it wants to come to fruition and funds the research that makes them possible.

Sometimes, the DoD will pick just one organization to handle the research for a project – but in other instances, a massive project is broken down into different facets and shared among a handful of organizations based on their areas of expertise.

As a medical research company, Burst Biologics is committed to helping the military and our nation’s servicemen and women through pioneering biomedical research. Our next step is to look for DoD solicitations that we can fulfill and apply for grants. This will help cover the costs as we conduct research in-house today that will support the health and well-being of our troops tomorrow.

The Future of Regenerative Medicine Solutions

Regenerative medicine couldn’t have come at a better time. According to the Centers for Disease Control and Prevention, about half of all adults in the United States (117 million people) suffered from one or more chronic health conditions.

This is an alarming statistic, particularly because most treatments for chronic diseases today are simply palliative – they don’t do much to prevent or delay disease progression or the onset of complications.

While regenerative medicine is still a burgeoning field, there’s already evidence to suggest that it can address the underlying mechanisms and causes of disease, in a way that’s never been possible before.

Here are a few examples we’re likely to see soon:

  • Cell therapy targeting blood cancers and solid tumors.
  • Gene therapy for genetic diseases and chronic conditions.
  • Gene editing to modify the genetic material of a patient’s cells to cure a range of diseases all at once.

If there’s one key takeaway here, it’s that we should no longer think of regenerative medicine solutions merely as “the future.”

The future is here now, making a difference in the lives of civilians and service members – and Burst Biologics is proud to be among those ranks, rethinking and evolving science every day.


Got Stem Cells on the Brain?

As we’ve mentioned before, Burst Biologics has its own lab and a staff of Ph.Ds working to make contributions to science, but we also follow what’s going on in our industry as a whole. There have been some amazing developments in the fields of biology and regenerative medicine over the last few years, like this exciting new study released in Stem Cell Journal on July 11 about the use of neural stem cells in the brain.

We thought the study was so interesting that we wanted to pass it along to you! 

Moving Neural Stem Cells

Human neural stem cells

Picture a big brick building on the riverfront. You walk up to it and notice that one corner of the building has suffered some serious water damage, probably from a recent flood. To fix the problem, you’ll have to redo some of the masonry, and in order to do that, you need to get bricks to the construction site.

Unfortunately, moving bricks poses a bit of a challenge. Access to the site by land is restricted, and the water is flowing the wrong way for an easy trip by boat. As you ponder the situation, you quickly realize that it doesn’t matter how well-made your bricks are – they won’t do any good unless you can get them where they’re needed.

In the case of the study “Electrical Guidance of Human Stem Cells in the Rat Brain,” researchers were faced with a similar dilemma: how do you get viable neural stem cells to the part of the brain where they can actually be useful in repairing damaged brain tissue?

An Electric Idea

What these scientists found was that they could mobilize and guide neural stem cells in the brain in vivo through electric stimulation.

They transplanted human neural stem cells (hNSCs) into the rostral migration stream (RMS). This pathway is a mechanism in the brain unique to certain animals, including rodents, rabbits, and monkeys. (Humans have one too, but it’s nowhere near as substantial as in other mammals, particularly rats.)

Along this special migratory route, neurons can differentiate once they reach the olfactory bulb (OB). However, with the application of an electric field, transplanted cells migrated against the endogenous cues. In other words, instead of going toward the OB, these neural stem cells moved deeper into the brain.

Intermittent electrical current drives human neural stem cells

In the case of our brick building scenario, it would be like moving bricks to the construction site against a river current. You’d obviously need a special kind of boat to get there, and any effort would pose its own challenges. For example, if you used an electric-powered speedboat, you would have to confront the other unique difficulty in this case, which is working safely with electricity.

The reality is, you don’t want to introduce a direct current electric field to the brain. This would induce a dangerous, potentially brain-frying Joule effect – and we doubt these rats did anything to deserve the electric chair!

As an alternative, the researchers devised an intermittent electric field technique that minimized the detrimental effects and still managed to guide the migration of hNSCs and maintain cell viability. With this strategy in place, no animals suffered seizures or other obvious complications from the electric fields.

What Researchers Found

The ultimate results of the study were well worth noting. In looking at the rat brains at three weeks and again at four months after the electrical stimulation, researchers saw that NSCs had migrated from the injection site to the lateral ventricle (LV) region and the contralateral hemisphere of the brain, against intrinsic guidance mechanisms. What’s more, the effect of the electric stimulation continued to work even after the stimulation stopped!

Obviously, there’s a lot more to this study than we can delve into here, but the fundamental idea behind it is fascinating to consider. There may be profound implications for healing brain damage and reversing degenerative brain conditions in humans.

It also goes to show that there’s nothing more exciting than thinking up novel solutions to problems that have confounded scientists in the past, especially as new technology becomes available.

As our lab techs and researchers approach new challenges, these are the kinds of stories that inspire us – and we hope they inspire you too!


A “Mismatch” Made in Heaven: Avoiding Graft-Versus-Host Disease (GvHD) With UCB

Matches aren’t just for online dating.

A Match Enjoying the Beach

In regenerative cell mediated therapy, you’re also looking for a certain type of match. But rather than long walks on the beach or a shared affinity for Jimmy Buffett tunes, you’re specifically seeking compatibility between the donor and recipient’s human leukocyte antigen (HLA) markers.

In many prominent regenerative medicine treatments, an imperfect HLA match means a high likelihood of developing graft-versus-host disease (GvHD) or suffering from a tissue rejection event. These are essentially two sides of the same coin:

  1. In GvHD, a certain population of the transplanted cells thinks your body is a foreign threat and attacks it.
  2. With tissue rejection, your body thinks the transplanted cells are a foreign threat and attacks them.

Now, because Burst Biologics uses umbilical cord blood as a source, our products don’t elicit such a response. But in regenerative therapy generally, an imperfect match could eventually interfere with the success of your treatment and lead to a host of side effects and complications.

GvHD manifests in one or more parts of the body – such as the skin, eyes, gut, and lungs – and occurs in two main forms:

Acute (aGvHD). Sudden onset, short-term condition with flu-like symptoms, such as fever, nausea, and irritated skin.  

Chronic (cGvHD). An autoimmune condition resembling lupus. Symptoms include dry mouth, shortness of breath, difficulty swallowing, muscle weakness, vision trouble, and abdominal swelling.

There’s a wide range in the severity of GvHD cases. Some patients experience nothing more than a mild rash, while others battle life-threatening symptoms due to GvHD.

In most cases, doctors will use immunosuppressant drugs to treat the condition. By tamping down the immune response, the body can sometimes power through the getting-to-know-you phase of a cellular allograft or replacement organ.

Unfortunately, this doesn’t always work.

There are times when a bad match starts to cause dangerous symptoms. That’s why it’s risky to rely on treatment after the fact to deal with GvHD. The better way is to help patients avoid GvHD in the first place.

You can do this by deriving cells from a source that doesn’t require doctors to play “matchmaker” with donor and recipient HLA markers: umbilical cord blood.

Matches Are Overrated

Generally, when doctors talk about regenerative medicine, they think of bone marrow. Over the years, that’s become the de facto source of mesenchymal derived stem cells to use in treating a range of diseases and disorders.

Bone marrowBut even though it’s widely known that mesenchymal stem cells have an immunomodulatory effect on immune cells, there are still a few key challenges in relying on bone marrow as a stem cell source.

First, as donor age increases, the efficacy of bone marrow derived stem cells declines. You don’t want to risk complications for a transplant that has little chance of actually doing what it’s supposed to do!

Second, aspiration of bone marrow is invasive, which makes it more difficult to depend on as a widespread source for stem cells.

Third, and perhaps most significantly, bone marrow derived stem cells require a virtually perfect match if you want to avoid graft-versus-host disease or a tissue rejection event.

That’s where umbilical cord blood (UCB) cells come in. Because they have an age of just nine months, UCB cells have underdeveloped HLA markers, so you don’t need a close match with UCB cells to avoid the dreaded immune response.

Because UCB mismatches are widely tolerated in patients, it’s possible for patients to use umbilical cord blood derived stem cells and their signaling molecules to enjoy a greatly reduced risk of GvHD or a tissue rejection event.

To see the potential immune response to UCB cells for ourselves, we actually conducted a mixed lymphocyte reaction study in our own laboratory.

A Burst Biologics Study

For our study, we took venous blood from three healthy adult volunteers, and then we treated each sample with cells from three separate BioBurst Fluid UCB donors, for a total of nine different combinations. This ensured a high likelihood of HLA mismatch, the very environment where graft-versus-host disease conditions should thrive.

Graft-versus-host disease (GvHD) mixed lymphocyte reaction study

After six days of co-culture incubation, we measured the lymphocyte proliferation. Our finding was that BioBurst Fluid does not cause an immune response, due to a lack of peripheral blood lymphocyte proliferation increase. In other words, we’ve seen no evidence of graft-versus-host disease developing from BioBurst UCB cells in our studies.

Of course, the lab and the real world are two different realms, so along with this internal study, we established an independent adverse event reporting database for our BioBurst products. To date, we’ve had zero incident reports of graft-versus-host disease or tissue graft rejection events.

Feel free to see the results of our study – BioBurst Fluid Cellular Allograft Does Not Elicit an Immune Response in Mixed Lymphocyte Reaction – posted in the BioPortal on our website.  

Further Research on UCB Safety

Of course, you don’t have to just take our word for it! This study conducted by Rajni Vyas et al in 2014 also found that unmatched allogeneic umbilical cord blood mononuclear cell transplantations didn’t elicit an immune response in allograft recipients.

There were some side effects reported, such as mild fever and headache, but “no GvHD or serious adverse effects were observed.” The haematological and biochemical parameters remained within the normal range, indicating a lack of immune response.

In a nutshell, these studies – along with countless patient cases – demonstrate that you can use minimally matched cell populations  from umbilical cord blood in transplant recipients with a minimal incidence of GvHD.

What’s more, this is achieved without the need for immunosuppressive therapy. BioBurst patients routinely benefit from the growth factor production and multipotency of UCB mononuclear cells, all while minimizing the risk of developing GvHD.

UCB derived cells also have an immune modulating activity, as described in this 2017 study. As an innate property, immunomodulation adds one additional layer of protection against patients developing GvHD or experiencing a graft tissue rejection event, while also serving as a potential solution for treating aGvHD after allogeneic tissue transplantation.

Minimizing GvHD

The bottom line is, matches aren’t all they’re cracked up to be. Umbilical cord blood derived stem cells are likely safer than the more commonly used bone marrow stem cells, and it’s because UCB derived cells possess underdeveloped HLA markers that are more unlikely to trigger an immune response.

It’s also important to remember that with BioBurst, your body isn’t trying to adjust to a permanent new crop of cells. Instead, the product features many signaling molecules and growth factors – messengers who arrive on the scene and tell your body to do its job. As long as the body doesn’t react with GvHD over that short initial time frame,  it’s possible to get all the benefits of a cellular allograft without the complications.  

That’s what the facts bear out about UCB derived cells in general, but we make the cellular allograft even safer (and more effective) with our Progenokine Process. This patent pending tissue processing methodology eliminates the unwanted components of umbilical cord blood samples, leaving behind only the desirable cell population, growth factors, and signaling molecules.

Ultimately, if you’re looking to avoid graft-versus-host disease, BioBurst products are a great choice. We’ve designed to reduce GvHD to a thing of the past.

Sources:

  1. Clinical safety in using unmatched allogeneic umbilical cord blood mononuclear cells transplantations in non-haematopoietic degenerative conditions
  2. Immunomodulatory function of whole human umbilical cord derived mesenchymal stem cells
  3. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells
  4. (Our own study) BioBurst Fluid cellular allograft does not elicit an immune response in vitro 

What is Regenerative Medicine Today?

Prometheus regenerating liver

We all remember Prometheus.

As you’ve probably heard us mention a time or two, Burst Biologics is in the business of regenerative medicine – and yes, it’s as cool as it sounds!

But what does regenerative medicine mean?

At its core, it’s all about helping human cells, tissues, and organs work properly. This branch of medicine focuses on the way cells live and function every day.

Compared to the whole of medicine, this is one field that’s quite new. However, forms of regenerative medicine have been practiced for more than 1000 years, and were acknowledged conceptually even in Ancient Greece. Remember Prometheus and his regenerating liver?

Of course, what we think of as regenerative medicine today is closely associated with the emergence of tissue engineering back in the late 1980s. It’s all based on the way cells work.  

The Magical Regenerating Cell

You have trillions of cells in your body, and they’re constantly regenerating. That’s the basic explanation for why you can donate blood, get a haircut, or heal from a broken bone.

Some types of cells replace themselves quickly, like the stomach cell’s two to nine day lifespan. Others last much longer, like the four month renewal rate for red blood cells.

But in any case, the concept of regenerative medicine hinges on this idea of regenerating cells.

Defining Regenerative Medicinecells can be replaced or regenerate

So, to better understand regenerative medicine, we need to consider what would happen if a group of cells in your body weren’t operating at their best. Conceptually, what could we do to fix that problem?

From the purview of regenerative medicine, it comes down to two general remedies.

 

Replacement

One clear solution is to replace the deficient cells or tissues with healthy ones. That’s essentially what an organ transplant is. If you have a failing kidney, swapping it out for a new one can rapidly restore functionality.

Replacement can be difficult, expensive, and invasive – but sometimes, it’s the only recourse available to patients with serious damage to their tissue or organs. With regenerative medicine, it’s possible to grow the new tissue that’s needed for replacement.

Regeneration

Another option is to regenerate the tissues and encourage self-healing. With this approach, you’re simply helping the body do what it normally could do, kind of like filling up the gas tank in a car that’s stalling.

One of our products is a fluid that aids and supports various mechanisms which encourage bone consolidation. Obviously, the body already knows how to heal bones, but this product aids in regulating the micro-environment to be one that encourages bone consolidation so that patients recover more quickly.

If you were to see what’s happening at a cellular level, you’d notice signaling molecules like growth factors and cytokines swooping onto the scene of an injury. These cytokines interact with cell receptors in local host cells, and can trigger a response indicative of wound healing. Basically, almost as if leading by example, these healthier cells demonstrate the way the host cells should be working, encouraging them to get back to their former, healthy selves.

Cells Themselves

The field of regenerative medicine relies heavily on advances in tissue engineering, and exemplifies plausible use cases for cellular and a-cellular allografts. But you’ve probably heard a good deal of talk about “stem cells”, and wonder how that plays a part. A good way to think of regenerative medicine is as if it’s a company, in a thriving economy. This one company is made up of different departments, and within those departments are different job descriptions and different individuals filling them.

The focus for regenerative medicine has been on “stem cells”, here at Burst Biologics we believe that’s not the best way to look at regenerative medicine. It’s so much more than that. Instead, try to think of stem cells as a single worker, in a single department, of a whole company. Yes, it does its part. Yes, it makes the whole team complete. But the rest of the team isn’t relying on the existence of that one worker to do their own jobs. 

The Future of Regenerative Medicine

The potential applications of regenerative medicine are truly profound. With tissue engineering and regenerative medicine products, physicians have the building blocks they need to change, repair, and grow damaged tissue in patients.

Previously impossible treatments are theoretically possible using regenerative medicine, reversing the effects of aging, organ failure, chronic wounds, and lifestyle diseases. The future of regenerative medicine – and the medical field as a whole – has never been brighter!

 

 


Here’s Why We Love Signaling Molecules

Cells are a lot like people: they have different jobs to do, and they need to work together to get them done. But rather than communicate using text messages or video chats, cells rely on chemical messengers called signaling molecules.

Here at Burst Biologics, we make a big deal about signaling molecules. Cell phone communicationThat’s because biologic products without functional signaling molecules are like cell phones without a cell signal – they just don’t work.

To understand the need for signaling molecules like growth factors and cytokines in regenerative medicine, let’s take a closer look at how signaling molecules operate at the cellular level.

Signaled and Delivered

All multicellular organisms – including plants and animals – rely on the interactions among cells in order to survive. One great example of cell communication is the hormone insulin, which springs into action to clear the sugar from your bloodstream after eating.  

But how does this signaling stuff work, exactly?

Well, when your body needs something to happen, one of your cells will produce a signaling molecule (or ligand). This heads to a target cell and makes it do its job. The interaction between cells can take place over all kinds of distances:

  • Signaling molecules diagramDirect cell-cell communication (adjacent distances): Sends the signaling molecule through gap junctions between touching cells, like one person whispering in another person’s ear.
  • Autocrine (to self): Sends the signaling molecule to self, like someone who writes a note on their own hand.
  • Paracrine (short distances): Sends the signaling molecule locally, like someone passing along a note to a friend.
  • Endocrine (long distances): Sends the signaling molecule across the whole body, like shipping a message to a friend by postal service.

With so many different cells, there are a wide variety of signaling molecules that interact with them across a range of distances. And just like certain keys can only fit certain locks, the incoming signaling molecule must be the right fit for receptors on a cell’s surface or within the cell.

Only then can a cellular response take place.

The Signaling Molecule Cytokine’s Job

One of the most important classes of signaling molecules is the cytokine, which plays an essential role in inflammation and immunity.

Cell receptor for signaling moleculesMany diseases occur when there’s some defect in the process between receiving a signaling molecule and generating a cell response. Sometimes, the body just isn’t equipped to do it anymore. In our regenerative medicine products, it’s the newly introduced cellular derived molecules that come to the rescue – they carry signaling cues that guide the receptive cells in your body to heal, grow, or change. It’s a pretty incredible process!

Burst Biologics products feature some key cytokines, including the interleukins IL-1beta, IL-2, IL-6, and IL-10. These are autocrine and paracrine in nature, which means they are sent and received by the same cell or wander to nearby cells.

When interleukins and growth factors like these are introduced in a medical procedure, they help inform the target cells on how to do their jobs better. This is a potent avenue in medicine, and we’re excited to be on the cutting edge!

Better With Progenokine

Clearly, regenerative medicine and biologics wouldn’t be the same without signaling molecules. That’s why we’re proud of our patent pending Progenokine Process for preserving the signaling molecules in our products.

The methodology we follow ensures that our products have the greatest possible impact for patients. We wouldn’t have it any other way.

To learn more about our products containing signaling molecules, visit our products page!


Dr. Gershon: Success Using Regenerative Medicine


Burst Biologics – Dr. Julian Gershon Success Using Regenerative Medicine

REGENERATIVE MEDICINE AND BIOBURST REJUV

Owner of the Aspen Institute, Dr. Julian Gershon, sat down and spoke with us about his involvement in the field of regenerative medicine and the benefit of our products at his practice. After finding personal success using BioBurst products, Dr. Gershon made it his goal to share his findings with patients.

Within the past year, Dr. Gershon has seen tremendous results using our product, BioBurst Rejuv. Beyond current use and applications, Dr. Gershon is especially excited for a future in exploring new applications of our product. “Really, I’m excited about using the BioBurst product with more patients.” After touring the facilities, Dr. Gershon sees the depth of knowledge and understanding with regard to how our products work at a cellular level. “I think we will see the BioBurst products used generally throughout medicine in the future, not just for orthopedic injuries.”

It was evident in our interview that Dr. Gershon is passionate about his practice, patients, and confident that cellular allografts are an extremely powerful source of regenerative medicine. ” I love sharing and making a difference in patients’ lives using this product.”

Want more? Check out our last blog here. Stay tuned for future blogs featuring the latest at Burst Biologics.

 


Motor Proteins: Biological engineering at its finest

Have you ever wondered what makes your cells divide when they copy themselves? Or, how things get carried from one part of a cell to another? Biological engineering has given us these “peg-legged” looking characters that “carry cargo” all around our cells. These characters, like pictured in the below video by the Hoogendaas Lab, are more accurately known as motor proteins.

VIDEO: A Day in the Life of a Motor Protein by Hoogendaas Lab

As the name may imply, motor proteins are a class of molecular motors that carry cellular material such as food, signaling molecules, and even genetic information. Just like a modern day taxi driver transporting you, precious cargo. Kinesin, the biological name of this “walking” protein, and other motor proteins use what is called the microtubule cytoskeleton to move cellular material around our bodies. This network of proteins is essentially what gives each of our cells its own unique structure. Now you’re probably wondering how this protein is able to move in such a unique way. In order for Kinesin to move, each foot uses chemical energy in high-packed molecule from, otherwise known as ATP. A typical Kinesin motor protein can travel at the rate of about one micrometer per second. That’s roughly 0.000002 miles per hour. Not quite a Lamborghini, but it get’s the job done.

Kinesin and the other molecular motors such as Myosin and Dynein are important because, without them, our genetic and other crucial cellular material wouldn’t be distributed to the trillions of new cells we make every day.

Without these molecular motors transporting material correctly, we may be more susceptible to cytoskeletal diseases such as Alzheimer’s. While this is concerning, new research and studies in the area of umbilical cord blood derived stem cells concludes that stem cells have the ability to protect damaged motor neurons and promote their regeneration.

So while you may have never known about these amazing microtubule walking proteins, know that they indeed play a key role in the functioning of our cells.

Want to know where Burst Biologics’ research is headed in regard to CNS diseases? Check out our BioTalk here with research scientist, Randy Ryan, PhD.

 

featured image — a Kinesin motor protein illustration by XVIVO


Scientific Discovery: The future for gene editing

In Radiolabs podcast, “Antibodies Part 1: CRISPR”  scientists talk about the hidden gem inside some of the world’s smallest organisms. CRISPR could possibly be one of the most powerful tools scientists have ever stumbled across. The excitement rises over this scientific discovery as it explores the future for gene editing and the potential to rewrite the way we change DNA.

Why is this so important? Gene editing may be the key to preventing things such as cancer and other life threatening diseases.

For the first time, there is a possibility for a gene editing technology that can be cheap, precise, and possibly universal.

As of this year, Jennifer Doudna and Emmanuelle Charpentier were awarded the Japan Prize for their invention of the revolutionary gene-editing technology known as CRISPR-Cas9 which has swept into research labs around the world. CRISPR-Cas9 is already yielding new therapies for cancer and hereditary diseases.

Check out the podcast by clicking play below or heading over to radiolab.

 

GUESTS:
Jennifer Doudna, Eugene V. Koonin, Beth Shapiro and Carl Zimmer

CHECK OUT MORE FROM RADIOLAB:

Radiolab Podcast Articles